Name | Tanshinone I |
Synonyms | Tanshinone TANSHINON I Tanshinone I TANSHINONE I AKOS NCG1-0066 TANSHINONES IIA 1,6-Dimethyl-phenanthro[1,2-b]furan-10,11-dione 1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione 3,8,8-TRIMETHYL-8,9,10,11-TETRAHYDROPHENANTHRO[1,2-B]FURAN-1,2-DIONE 1,6,6-TRIMETHYL-6,7,8,9-TETRAHYDRO-PHENANTHRO[1,2-B]FURAN-10,11-DIONE |
CAS | 568-73-0 |
InChI | InChI=1/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3 |
Molecular Formula | C18H12O3 |
Molar Mass | 276.29 |
Density | 1.324±0.06 g/cm3(Predicted) |
Melting Point | 233-234°C |
Boling Point | 498.0±24.0 °C(Predicted) |
Solubility | Soluble in chloroform, soluble in organic solvents such as acetone, slightly soluble in water. |
Appearance | Brown red crystal |
Color | red |
Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
Sensitive | Sensitive to light |
MDL | MFCD00210563 |
Physical and Chemical Properties | Deep Red Crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Salvia miltiorrhiza rhizome. |
In vitro study | Tanshinone I, an active ingredient isolated from Danshen, is structurally similar to tanshinone IIA and has similar cytotoxic effects on tumor cells. Tanshinone I inhibited the formation of PGE 2 in LPS-induced RAW macrophages (IC50=38 μm). However, this compound did not affect COX-2 activity or COX-2 expression. Tanshinone I is an inhibitor of Type IIA human recombinant phospholipase A 2 (PLA 2) with an IC50 of 11 μm. In the initial data, tanshinone I had the strongest inhibitory effect on tumor necrosis factor-& α;(TNF-& α;)-induced adhesion molecules. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29329990 |
Reference Show more | 1. Li Xiaomei, Qin Guimei. In vitro antibacterial effect of aloe-Salvia miltiorrhiza compound gel on main pathogenic bacteria of acne [J]. Chinese Journal of medical innovation, 2014, 000(026):104-106. 2. Hu Weihui, Han Dong, Qijiang Kun, et al. Simultaneous determination of 12 components in Salvia przewalskii by RP-HPLC [J]. Journal of Pharmaceutical Analysis 2016 v.36(03):486-493. 3. Cheng Pei, Han Dongqi, Hu Weihui, etc. Simultaneous determination of 10 water-soluble and 4 fat-soluble components in Salvia miltiorrhiza by high performance liquid chromatography [J]. Journal of Pharmaceutical Analysis, 2015(06):991-996. 4. Sun jinlinli, Peng Min, et al. Comparison of 12 components extracted from Salvia miltiorrhiza by different concentrations of ethanol [J]. Chinese Journal of Information on traditional Chinese medicine 2019(9). 5. Zhang ruigan, Wu Xiaoyi, Hu Tianyuan, Song Yadi, Gao Wei, Huang Luqi. Study on quality markers of Salvia miltiorrhiza based on biogenic pathway of Tanshinones [J]. Chinese Journal of Traditional Chinese Medicine, 2020,45(13):3098-3103. 6. Zhang Yu, Qi Yingxue, Wang Lei, etc. Study on regional distribution characteristics of liposoluble components in Salvia miltiorrhiza in Shandong province [J]. Chinese herbal medicine, 2018, 041(011):2522-2526. 7. Yan Shi Lei Shi Ning Guo Hong cited Geng Shuai Wen Binyu. UPLC-Q-TOF-MS simultaneous determination of main components of Salvia miltiorrhiza in Tianwang Buxin tablets [J]. Chinese PLA Journal of Pharmacy 2018 34(01):55-57. 8. Li Qingqing, Zhang Jifen. Determination of 14 components in guanxinning [J]. Suyan science & technology 2019 046(006):33-35. 9. Wang Yun, Chen Junfeng, Zhang Lei, et al. Evaluation of quality of Salvia miltiorrhiza Bunge based on association analysis of "active components-traits" [J]. World Science and Technology: modernization of traditional Chinese medicine, 2019(5):835-843. 10. Cui Weiliang. Comparison of the distribution of chromatographic peaks of HPLC fingerprint before and after the processing of Danshen wine [J]. Liaoning Journal of Traditional Chinese Medicine, v.46;No.507(08):1707-1709. 11. Wang, Yang, et al. "Identification of Salvia species using high‐performance liquid chromatography combined with chemical pattern recognition analysis." Journal of separation science 41.3 (2018): 609-617.https://doi.org/10.1002/jssc.201701066 12. [IF=7.514] Tiehua Zhang et al."In vitro and in silico perspectives on estrogenicity of tanshinones from Salvia miltiorrhiza."Food Chem. 2019 Jan;270:281 13. [IF=3.645] Yang Wang et al."Identification of Salvia species using high-performance liquid chromatography combined with chemical pattern recognition analysis."J Sep Sci. 2018 Feb;41(3):609-617 14. [IF=3.414] Yu-xiang Fei et al."Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats."J Ethnopharmacol. 2017 Jul;207:57 15. [IF=7.514] Tong Wang et al."A hydrophobic deep eutectic solvents-based integrated method for efficient and green extraction and recovery of natural products from Rosmarinus officinalis leaves, Ginkgo biloba leaves and Salvia miltiorrhiza roots."Food Chem. 2021 Nov;3 16. [IF=6.475] Shi Qiu et al."Selection of appropriate post-harvest processing methods based on the metabolomics analysis of Salvia miltiorrhiza Bunge."Food Res Int. 2021 Jun;144:110366 17. [IF=4.411] Yuanyuan Li et al."Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy."Molecules. 2020 Jan;25(9):2043 18. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 19. [IF=3.69] Qian Zhang et al."Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia."J Ethnopharmacol. 2020 Apr;252:112573 20. [IF=3.411] Liu Hongyan et al."Effect Study of Continuous Monoculture on the Quality of Salvia miltiorrhiza Bge Roots."Biomed Res Int. 2020;2020:4284385 21. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 22. [IF=2.1] Yuyan Zhang et al."Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression."Mol Med Rep. 2021 Jan;23(1):1-1 23. [IF=6.057] Qi Tong et al.Biosynthesis-based spatial metabolome of Salvia miltiorrhiza Bunge by combining metabolomics approaches with mass spectrometry-imaging.Talanta. 2021 Nov;:123045 24. [IF=7.376] Chengtao Sun et al."Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation."Free Radical Bio Med. 2022 Feb;180:220 |
Plant Source: | Salvia miltiorrhiza |
biological activity | Tanshinone I was isolated from Salvia miltiorrhiza. |
Target | Value |
PLA2 () | 11 μM |
Use | Tanshinone I has the effect of treating acne, pustular acne and angina pectoris. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: used for chest and rib flank pain, rheumatism pain, syndrome block, sore pain, falling pain, irregular menstruation, dysmenorrhea, postpartum stasis pain. Treatment of chest rib pain, inflammation and block, as well as irregular menstruation, amenorrhea pain with good effect, often with the application of Ligusticum Chuanxiong. In the treatment of chest and abdominal pain belongs to qi stagnation and blood stasis, often with amomum villosum, sandalwood and other drugs. |